No study has ever examined the effect of vitamin C with metformin on fasting (FBS) and postmeal blood glucose (PMBG) as well\nas glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to examine the effect of\noral vitamin C with metformin on FBS, PMBG, HbA1c, and plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients\nwith type 2 DMparticipated in a prospective, double-blind, placebo-controlled, 12-week study. The patients with type 2 DMwere\ndivided randomly into placebo and vitamin C group of 35 each. Both groups received the treatment for twelve weeks. Decreased\nPAA levels were found in patients with type 2 diabetes mellitus. This level was reversed significantly after treatment with vitamin\nC along with metformin compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed significant improvement\nafter 12 weeks of treatment with vitamin C. In conclusion, oral supplementation of vitamin C with metformin reverses ascorbic\nacid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in combination may be used in the treatment of type\n2 DM to maintain good glycemic control.
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